The 2012 San Marino CEPU Open was a professional tennis tournament plays on clay courts. It was the 25th edition of the tournament which is part of the Tretorn SERIE+ of the 2012 ATP Challenger Tour. It takes place in City of San Marino, San Marino between 6 and 12 August 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Slovakia | Martin Kližan | 52 | 1 | |
| Blaž Kavčič | 76 | 2 | ||
 Italy | Filippo Volandri | 80 | 3 | |
 Spain | Albert Montañés | 90 | 4 | |
 Brazil | Rogério Dutra da Silva | 95 | 5 | |
| Italy | Simone Bolelli | 104 | 6 | |
| Spain | Daniel Gimeno Traver | 108 | 7 | |
| Italy | Potito Starace | 112 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Claudio Grassi
Stéphane RobertSee main article: 2012 San Marino CEPU Open – Singles.
Martin Kližan def. Simone Bolelli, 6–3, 6–1[1]See main article: 2012 San Marino CEPU Open – Doubles.
Lukáš Dlouhý / Michal Mertiňák def. Stefano Ianni / Matteo Viola, 2–6, 7–6(7–3), [11–9]