| Champ: |  Rubén Ramírez Hidalgo |
| Runner: |  Paolo Lorenzi |
| Score: | 3–6, 6–3, 6–4 |
| Type: | men |
| Before Year: | 2009 |
See main article: 2012 San Luis Potosí Challenger.
Santiago Giraldo was the defending champion but decided not to participate. Spanish Rubén Ramírez Hidalgo won the tournament with the score 3–6, 6–3, 6–4 in the final against Paolo Lorenzi.