See main article: 2012 San Luis Potosí Challenger. Santiago González and Horacio Zeballos were the defending champions but decided not to participate.
Nicholas Monroe and Simon Stadler won the title, defeating Andre Begemann and Jordan Kerr 3–6, 7–5, [10–7] in the final.
James Cerretani / John Paul Fruttero (first round)
Jordan Kerr (final) Nicholas Monroe / Simon Stadler (champions) Colin Ebelthite / Nima Roshan (first round)