The 2012 San Luis Potosí Challenger was a professional tennis tournament played on clay courts. It was the 19th edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in San Luis Potosí, Mexico between 2 and 8 April 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Paolo Lorenzi | 81 | 1 | |
 Spain | Rubén Ramírez Hidalgo | 121 | 2 | |
| Spain | Arnau Brugués-Davi | 152 | 3 | |
| Italy | Matteo Viola | 154 | 4 | |
 Czech Republic | Jan Mertl | 211 | 5 | |
 Canada | Érik Chvojka | 223 | 6 | |
 Moldova, Republic of | Roman Borvanov | 235 | 7 | |
 Colombia | Alejandro González | 255 | 8 |
The following players received wildcards into the singles main draw:
Luis Patino Miguel Angel Reyes-Varela Bruno Rodríguez Manuel SanchezThe following players received entry from the qualifying draw:
The following player received entry as a lucky loser into the singles main draw:
See main article: 2012 San Luis Potosí Challenger – Singles.
Rubén Ramírez Hidalgo def. Paolo Lorenzi 3–6, 6–3, 6–4See main article: 2012 San Luis Potosí Challenger – Doubles.
Nicholas Monroe / Simon Stadler def. Andre Begemann / 
Jordan Kerr 3–6, 7–5, [10–7]
