| Date: | February 17–26 |
| Edition: | 37th (men) / 27th (women) |
| Category: | ATP World Tour 500 |
| Surface: | Hard |
| Location: | Memphis, Tennessee, US |
| Venue: | Racquet Club of Memphis |
| Champms: |  Jürgen Melzer |
| Champws: |  Sofia Arvidsson |
| Champmd: |  Max Mirnyi /  Daniel Nestor |
| Champwd: |  Andrea Hlaváčková / Lucie Hradecká |
| After Year: | 2013 |
The 2012 Regions Morgan Keegan Championships and the Memphis International was an ATP World Tour and WTA Tour event held at the hardcourts of the Racquet Club of Memphis in Memphis, Tennessee, US. It was the 37th edition of the Regions Morgan Keegan Championships and the 27th edition of the Memphis WTA International Event. The Regions Morgan Keegan Championships was part of the ATP World Tour 500 series on the 2012 ATP World Tour, and the Cellular South Cup was an International-level tournament on the 2012 WTA Tour. The event took place from February 17 to February 26, 2012. Jürgen Melzer and Sofia Arvidsson won the singles titles.
| Country | Player | Rank1 | Seeds | |
|---|---|---|---|---|
 United States | John Isner | 14 | 1 | |
| United States | Andy Roddick | 17 | 2 | |
| Czech Republic | Radek Štěpánek | 29 | 3 | |
| Canada | Milos Raonic | 32 | 4 | |
 Russian Federation | Alex Bogomolov, Jr. | 33 | 5 | |
 France | Julien Benneteau | 34 | 6 | |
| Kevin Anderson | 35 | 7 | ||
 Australia | Bernard Tomic | 36 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Belarus | Max Mirnyi | Canada | Daniel Nestor | 6 | 1 | |
| Jürgen Melzer | Philipp Petzschner | 30 | 2 | |||
| Czech Republic | František Čermák | Filip Polášek | 41 | 3 | ||
 Mexico | Santiago González | Christopher Kas | 42 | 4 |
The following pairs received wildcards into the doubles main draw:
| Country | Player | Rank1 | Seeds | |
|---|---|---|---|---|
| Russian Federation | Nadia Petrova | 32 | 1 | |
 Kazakhstan | Ksenia Pervak | 44 | 2 | |
| Czech Republic | Lucie Hradecká | 52 | 3 | |
 New Zealand | Marina Erakovic | 58 | 4 | |
| France | Pauline Parmentier | 59 | 5 | |
 United Kingdom | Elena Baltacha | 61 | 6 | |
| Sweden | Johanna Larsson | 62 | 7 | |
 Slovakia | Magdalena Rybáriková | 65 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Czech Republic | Andrea Hlaváčková | Czech Republic | Lucie Hradecká | 21 | 1 | |
| Vera Dushevina | Olga Govortsova | 105 | 2 | |||
| Līga Dekmeijere | Nadia Petrova | 106 | 3 | |||
| Michaëlla Krajicek | Anna Tatishvili | 163 | 4 |
The following pairs received wildcards into the doubles main draw:
Lauren Davis / Madison Keys Alyssa Hibberd / Tiffany WelcherThe following pair received entry as alternates:
Mariya Slupska Alexa Glatch (left Achilles tendon injury) Ksenia Pervak (viral illness) Nadia Petrova (left thigh injury)See main article: 2012 Regions Morgan Keegan Championships – Singles. Jürgen Melzer defeated Milos Raonic, 7–5, 7–6(4)
See main article: 2012 Memphis International – Singles. Sofia Arvidsson defeated Marina Erakovic, 6–3, 6–4
See main article: 2012 Regions Morgan Keegan Championships – Doubles. Max Mirnyi / Daniel Nestor defeated Ivan Dodig / 
Marcelo Melo, 4–6, 7–5, [10–7]
See main article: 2012 Memphis International – Doubles. Andrea Hlaváčková / Lucie Hradecká defeated Vera Dushevina / Olga Govortsova, 6–3, 6–4
