| Champ: |  Jürgen Melzer |
| Runner: |  Milos Raonic |
| Score: | 7–5, 7–6(7–4) |
| Draw: | 32 |
| Seeds: | 8 |
See main article: 2012 Regions Morgan Keegan Championships and the Cellular South Cup.
Andy Roddick was the defending champion, but lost in the first round to Xavier Malisse. Jürgen Melzer defeated Milos Raonic in the final 7–5, 7–6(7–4).