| Date: | 1–7 October |
| Edition: | 18th |
| Surface: | Clay |
| Location: | Quito, Ecuador |
| Champs: |  João Souza |
| Champd: |  Juan Sebastián Cabal / Carlos Salamanca |
| Before Name: | Cerveza Club Premium Open |
| After Name: | Quito Challenger |
| Before Year: | 2011 |
| After Year: | 2013 |
The 2012 Quito Challenger was a professional tennis tournament played on clay courts. It was the 18th edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Quito, Ecuador between 1 and 7 October 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Frederico Gil | 131 | 1 | ||
 France | Guillaume Rufin | 132 | 2 | |
 Argentina | Martín Alund | 134 | 3 | |
| Brazil | João Souza | 152 | 4 | |
| Argentina | Eduardo Schwank | 170 | 5 | |
 Dominican Republic | Víctor Estrella | 186 | 6 | |
| Colombia | Carlos Salamanca | 235 | 7 | |
 Ecuador | Júlio César Campozano | 247 | 8 |
The following players received wildcards into the singles main draw:
Joseph Correa Lucas Dages José Chamba GómezThe following players received entry from the qualifying draw:
Juan Carvajal
Miguel Ángel Reyes-Varela
Goran TošićSee main article: 2012 Quito Challenger – Singles.
João Souza def. Guillaume Rufin, 6–2, 7–6(7–4)See main article: 2012 Quito Challenger – Doubles.
Juan Sebastián Cabal / Carlos Salamanca def. Marcelo Demoliner / João Souza, 7–6(9–7), 7–6(7–4)