| Champ: |  Victoria Azarenka |
| Runner: |  Samantha Stosur |
| Score: | 6–1, 6–2 |
| Draw: | 56 |
| Seeds: | 16 |
| Type: | singles doubles |
| Before Name: | Qatar Ladies Open – Singles |
| After Name: | Qatar Total Open – Singles |
See main article: 2012 Qatar Total Open.
Victoria Azarenka defeated Samantha Stosur in the final, 6–1, 6–2 to win the singles tennis title at the 2012 WTA Qatar Open.
Vera Zvonareva was the defending champion, but retired during her second round match against Monica Niculescu.
The top eight seeds received a bye into the second round.