The 2012 Orbetello Challenger was a professional tennis tournament played on clay courts. It was the fourth edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Orbetello, Italy between 23 and 29 July 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Spain | Roberto Bautista Agut | 118 | 1 | |
 Italy | Matteo Viola | 155 | 2 | |
 Canada | Peter Polansky | 156 | 3 | |
 Argentina | Facundo Bagnis | 163 | 4 | |
| Italy | Gianluca Naso | 175 | 5 | |
 Belgium | Yannick Mertens | 217 | 6 | |
| Italy | Simone Vagnozzi | 223 | 7 | |
| Pedro Sousa | 232 | 8 |
The following players received wildcards into the singles main draw:
Marco Cecchinato Alessio di Mauro Matteo Marrai Walter TrusendiThe following players received entry as a special exempt into the singles main draw:
The following players received entry from the qualifying draw:
Jérôme Inzerillo
Dušan Lajović
Goran TošićSee main article: 2012 Orbetello Challenger – Singles.
Roberto Bautista Agut def. Dušan Lajović, 6–3, 6–1See main article: 2012 Orbetello Challenger – Doubles.
Stefano Ianni / 
Dane Propoggia def. Alessio di Mauro / Simone Vagnozzi, 6–3, 6–2