The 2012 Orange Open Guadeloupe was a professional tennis tournament played on hard courts. It was the second edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Le Gosier, Guadeloupe between 26 March – 1 April 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Belgium | Olivier Rochus | 52 | 1 | |
| Yen-Hsun Lu | 58 | 2 | ||
| James Blake | 69 | 3 | ||
 France | Édouard Roger-Vasselin | 89 | 4 | |
 Russian Federation | Igor Kunitsyn | 90 | 5 | |
| France | Nicolas Mahut | 92 | 6 | |
 Japan | Tatsuma Ito | 94 | 7 | |
| France | Benoît Paire | 96 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry as an alternate into the singles main draw:
The following players received entry as a special exempt into the singles main draw:
The following players received entry from the qualifying draw:
Dan Evans Pierre-Hugues Herbert
Ivo Klec Julien ObryThe following players received entry as a lucky loser into the singles main draw:
See main article: 2012 Orange Open Guadeloupe – Singles.
David Goffin def. Mischa Zverev, 6–2, 6–2See main article: 2012 Orange Open Guadeloupe – Doubles.
Pierre-Hugues Herbert / Albano Olivetti def. 
Paul Hanley / Jordan Kerr, 7–5, 1–6, [10–7]
