| Date: | 14–20 May |
| Edition: | 16th |
| Category: | ITF Women's Circuit |
| Location: | Saint-Gaudens, France |
| Surface: | Clay |
| Prize Money: | $50,000+H |
| Champs: |  Mariana Duque |
| Champd: |  Vesna Dolonc /  Irina Khromacheva |
The 2012 Open Saint-Gaudens Midi-Pyrénées was a professional tennis tournament played on outdoor clay courts. It was the 16th edition of the tournament which was part of the 2012 ITF Women's Circuit. It took place in Saint-Gaudens, France, on 14–20 May 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Russian Federation | Alexandra Panova | 79 | 1 | |
 Romania | Edina Gallovits-Hall | 85 | 2 | |
| Arantxa Rus | 87 | 3 | ||
 United States | Irina Falconi | 100 | 4 | |
 United Kingdom | Heather Watson | 110 | 5 | |
 Hungary | Melinda Czink | 122 | 6 | |
| Russian Federation | Valeria Savinykh | 125 | 7 | |
| United Kingdom | Laura Robson | 126 | 8 |
The following players received wildcards into the singles main draw:
Jessica Ginier Myrtille Georges Victoria LarrièreThe following players received entry from the qualifying draw:
The following players received entry as lucky losers:
The following players received entry by a Junior Exempt:
See main article: 2012 Open Saint-Gaudens Midi-Pyrénées – Singles.
Mariana Duque def. Claire Feuerstein 4–6, 6–3, 6–2See main article: 2012 Open Saint-Gaudens Midi-Pyrénées – Doubles.
Vesna Dolonc / Irina Khromacheva def. Naomi Broady / 
Julia Glushko 6–2, 6–0
