The 2012 Open GDF Suez de Cagnes-sur-Mer Alpes-Maritimes was a professional tennis tournament played on clay courts. It was the fifteenth edition of the tournament which was part of the 2012 ITF Women's Circuit. It took place in Cagnes-sur-Mer, France between 7 and 13 May 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 United Kingdom | Elena Baltacha | 63 | 1 | |
 Hungary | Tímea Babos | 64 | 2 | |
 Romania | Alexandra Cadanțu | 74 | 3 | |
| United Kingdom | Anne Keothavong | 75 | 4 | |
 Russian Federation | Alexandra Panova | 76 | 5 | |
 Japan | Ayumi Morita | 77 | 6 | |
| Japan | Kimiko Date-Krumm | 79 | 7 | |
 France | Stéphanie Foretz Gacon | 82 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry by a Junior Exempt:
See main article: 2012 Open GDF Suez de Cagnes-sur-Mer Alpes-Maritimes – Singles.
Yulia Putintseva def. 
Patricia Mayr-Achleitner, 6–2, 6–1See main article: 2012 Open GDF Suez de Cagnes-sur-Mer Alpes-Maritimes – Doubles.
Alexandra Panova / 
Urszula Radwańska def. Katalin Marosi / 
Renata Voráčová, 7–5, 4–6, [10–6]