The 2012 Open 13 was a men's tennis tournament played on indoor hard courts. It was the 19th edition of the Open 13, and was part of the World Tour 250 tier of the 2012 ATP World Tour. It took place at the Palais des Sports in Marseille, France, from 20 February through 26 February 2010. Fourth-seeded Juan Martín del Potro won the singles title.
| Country | Player | Ranking1 | Seeding | |
|---|---|---|---|---|
 France | Jo-Wilfried Tsonga | 6 | 1 | |
 United States | Mardy Fish | 8 | 2 | |
 Serbia | Janko Tipsarević | 9 | 3 | |
 Argentina | Juan Martín del Potro | 10 | 4 | |
| France | Richard Gasquet | 16 | 5 | |
| Alexandr Dolgopolov | 19 | 6 | ||
| Ivan Ljubičić | 41 | 7 | ||
 Italy | Andreas Seppi | 45 | 8 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Nikolay Davydenko (right foot injury) Adrian Mannarino (right wrist injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 India | Mahesh Bhupathi | India | Rohan Bopanna | 26 | 1 | |
| Paul Hanley | Jamie Murray | 86 | 2 | |||
| Jean-Julien Rojer | Igor Zelenay | 128 | 3 | |||
 Austria | Alexander Peya | Lukáš Rosol | 130 | 4 |
The following pairs received wildcards into the doubles main draw:
See main article: 2012 Open 13 – Singles. Juan Martín del Potro defeated Michaël Llodra, 6–4, 6–4
See main article: 2012 Open 13 – Doubles. Nicolas Mahut / Édouard Roger-Vasselin defeated Dustin Brown / Jo-Wilfried Tsonga, 3–6, 6–4, [10–6]
