The 2012 Nielsen Pro Tennis Championship was a professional tennis tournament played on hard courts. It was the 21st edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Winnetka, Illinois, between 2 and 8 July 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Benjamin Becker | 124 | 1 | ||
| Ryan Sweeting | 130 | 2 | ||
| Bobby Reynolds | 132 | 3 | ||
| Marco Chiudinelli | 134 | 4 | ||
| Rik de Voest | 142 | 5 | ||
 Ukraine | Sergei Bubka | 167 | 6 | |
 Lithuania | Ričardas Berankis | 169 | 7 | |
 Thailand | Danai Udomchoke | 171 | 8 |
The following players received wildcards into the singles main draw:
Mitchell Frank Bradley Klahn Dennis Nevolo Blake StrodeThe following players received entry as an alternate into the singles main draw:
The following players received entry from the qualifying draw:
Jeff Dadamo
Luka Gregorc
John-Patrick SmithSee main article: 2012 Nielsen Pro Tennis Championship – singles.
John-Patrick Smith def. Ričardas Berankis, 3–6, 6–3, 7–6(7–3)See main article: 2012 Nielsen Pro Tennis Championship – doubles.
Devin Britton / Jeff Dadamo def. John Peers / John-Patrick Smith, 1–6, 6–2, [10–6]