| Year: | 2012 |
| Team: | Mississippi Valley State Delta Devils |
| Sport: | football |
| Conference: | Southwestern Athletic Conference |
| Division: | East Division |
| Short Conf: | SWAC |
| Record: | 5–6 |
| Conf Record: | 5–4 |
| Head Coach: | Karl Morgan |
| Hc Year: | 3rd |
| Off Coach: | Ramon Flanigan |
| Oc Year: | 3rd |
| Stadium: | Rice–Totten Stadium |
The 2012 Mississippi Valley State Delta Devils football team represented Mississippi Valley State University as a member of the East Division of the Southwestern Athletic Conference (SWAC) during the 2012 NCAA Division I FCS football season. Led by third-year head coach Karl Morgan, the Delta Devils compiled an overall record of 5–6 and a mark of 5–4 in conference play, placing fourth in the SWAC's East Division. Mississippi Valley State played home games at Rice–Totten Stadium in Itta Bena, Mississippi.
All Delta Devils games were carried live on WVSD radio.