| Champ: |  Sofia Arvidsson |
| Runner: |  Marina Erakovic |
| Score: | 6–3, 6–4 |
| Draw: | 32 |
| Seeds: | 8 |
See main article: 2012 Regions Morgan Keegan Championships and Memphis International. Magdaléna Rybáriková is the defending champion, but she lost in the first round to the American qualifier Jamie Hampton.
Sofia Arvidsson won the title by defeating Marina Erakovic 6–3, 6–4 in the final. This was Arvidsson's second WTA title, with her first title won at the same event six years ago.