| Date: | 29 October–4 November |
| Edition: | 1st |
| Location: | New Braunfels, Texas, United States |
| Champs: |  Melanie Oudin |
| Champd: |  Elena Bovina / Mirjana Lučić |
The 2012 John Newcombe Women's Pro Challenge was a professional tennis tournament played on outdoor hard courts. It was the first edition of the tournament which was part of the 2012 ITF Women's Circuit. It took place in New Braunfels, Texas, United States, on 29 October–4 November 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Italy | Camila Giorgi | 77 | 1 | |
| Lauren Davis | 88 | 2 | ||
| Melanie Oudin | 98 | 3 | ||
| Mirjana Lučić | 109 | 4 | ||
| Michelle Larcher de Brito | 113 | 5 | ||
 Colombia | Mariana Duque | 170 | 6 | |
| Madison Keys | 173 | 7 | ||
| Chichi Scholl | 174 | 8 |
The following players received wildcards into the singles main draw:
Rosalia Alda Victoria Duval Yasmin SchnackThe following players received entry from the qualifying draw:
The following players received entry as Lucky Losers:
See main article: 2012 John Newcombe Women's Pro Challenge – Singles.
Melanie Oudin def. Mariana Duque 6–1, 6–1.See main article: 2012 John Newcombe Women's Pro Challenge – Doubles.
Elena Bovina / Mirjana Lučić def. Mariana Duque / 
Adriana Pérez 6–3, 4–6, [10–8].