The 2012 IS Open de Tênis was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in São Paulo, Brazil, on 23–29 April 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Slovenia | Blaž Kavčič | 104 | 1 | |
| Paul Capdeville | 113 | 2 | ||
 Brazil | Ricardo Mello | 123 | 3 | |
| Brazil | Rogério Dutra da Silva | 125 | 4 | |
| Brazil | Thiago Alves | 152 | 5 | |
 Argentina | Martín Alund | 158 | 6 | |
| Brazil | Júlio Silva | 166 | 7 | |
 Colombia | Carlos Salamanca | 176 | 8 |
The following players received wildcards into the singles main draw:
Enrique Bogo Tiago Fernandes Fernando Romboli João Pedro SorgiThe following players received entry as a special exempt into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky loser:
The following players withdrew from the main draw:
See main article: 2012 IS Open de Tênis – Singles.
Blaž Kavčič def. Júlio Silva, 6–3, 7–5See main article: 2012 IS Open de Tênis – Doubles.
André Ghem / João Pedro Sorgi, 7–5, 6–3
