See main article: 2012 French Open.
Defending champion Esther Vergeer and her partner Marjolein Buis defeated Sabine Ellerbrock and Yui Kamiji in the final, 6–0, 6–1 to win the women's doubles wheelchair tennis title at the 2012 French Open.
Vergeer and Sharon Walraven were the defending champions, but did not participate together. Walraven partnered Annick Sevenans, but was defeated in the semifinals by Ellerbrock and Kamiji.
Annick Sevenans / Sharon Walraven (semifinals)