See main article: 2012 Fifth Third Bank Tennis Championships. The 2012 Fifth Third Bank Tennis Championships women's singles was a professional tennis tournament played on outdoor hard courts in Lexington, Kentucky, United States.
Chichi Scholl was the defending champion, but lost in the first round to Bethanie Mattek-Sands.
Julia Glushko won the title, defeating Johanna Konta in the final, 6–3, 6–0.