The 2012 Family Circle Cup was a women's tennis event in the 2012 WTA Tour. It took place from March 31 to April 8, 2012. It was the 40th edition of the tournament and a Premier level tournament. The event was hosted at the Family Circle Tennis Center, on Daniel Island, Charleston, South Carolina, United States. It was the only event of the clay courts season played on green clay. The total prize money offered at this tournament was [1]
| Country | Player | Ranking1 | Seed | |
|---|---|---|---|---|
 Poland | ||||
 Australia | Samantha Stosur | 5 | 2 | |
 France | Marion Bartoli | 7 | 3 | |
 Russian Federation | Vera Zvonareva | 9 | 4 | |
| Serena Williams | 11 | 5 | ||
| Sabine Lisicki | 13 | 6 | ||
 Serbia | Jelena Janković | 15 | 7 | |
| Russian Federation | Anastasia Pavlyuchenkova | 21 | 8 | |
 Czech Republic | Lucie Šafářová | 25 | 9 | |
 Spain | Anabel Medina Garrigues | 27 | 10 | |
| Christina McHale | 32 | 11 | ||
 Belgium | Yanina Wickmayer | 33 | 12 | |
| Russian Federation | Nadia Petrova | 35 | 13 | |
| Polona Hercog | 38 | 14 | ||
| Chanelle Scheepers | 42 | 15 | ||
| Australia | Jarmila Gajdošová | 45 | 16 | |
 New Zealand | Marina Erakovic | 49 | 17 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
Akgul Amanmuradova Iveta Benešová
Jill Craybas
Melinda Czink
Mariana Duque-Mariño
Camila Giorgi
Paula Ormaechea Melanie Oudin Karolína Plíšková
Yaroslava ShvedovaThe following players received entry as lucky losers:
Irina-Camelia Begu (right elbow injury)
Zheng Jie (low back injury)
Ayumi Morita Agnieszka Radwańska (back injury) Peng Shuai (right shoulder injury) Jelena Dokić| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Liezel Huber | Lisa Raymond | 3 | 1 | |||
| Květa Peschke | Katarina Srebotnik | 7 | 2 | |||
 India | Sania Mirza | Elena Vesnina | 15 | 3 | ||
| Czech Republic | Andrea Hlaváčková | Lucie Hradecká | 19 | 4 |
The following pairs received wildcards into the doubles main draw:
Emily J. Harman / Simone Kalhorn Anastasia Pavlyuchenkova / Lucie ŠafářováSee main article: 2012 Family Circle Cup – Singles.
Serena Williams defeated Lucie Šafářová 6–0, 6–1.It was Serena's 40th career singles title and her 4th overall on clay.
See main article: 2012 Family Circle Cup – Doubles.
Anastasia Pavlyuchenkova / Lucie Šafářová defeated Anabel Medina Garrigues / Yaroslava Shvedova, 5–7, 6–4, [10–6]