| Main Name: | Portugal OpenEstoril Open |
| Champ: |  Kaia Kanepi |
| Runner: |  Carla Suárez Navarro |
| Score: | 3–6, 7–6(8–6), 6–4 |
| Before Name: | Estoril Open – Women's singles |
| After Name: | Portugal Open – Women's singles |
See main article: 2012 Estoril Open. Anabel Medina Garrigues was the defending champion, but lost in the second round to Sílvia Soler Espinosa.
Kaia Kanepi won the tournament, defeating in the final Carla Suárez Navarro 3–6, 7–6(8–6), 6–4.
