The 2012 Estoril Open was a tennis tournament played on outdoor clay courts. It was the 23rd edition of the Estoril Open for the men (the 16th for the women), and was part of the ATP World Tour 250 series of the 2012 ATP World Tour, and of the International-level tournaments of the 2012 WTA Tour. Both the men's and the women's events took place at the Estádio Nacional in Oeiras, Portugal, from 28 April through 6 May 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Juan Martín del Potro | 10 | 1 | |
 France | Richard Gasquet | 18 | 2 | |
| Stanislas Wawrinka | 22 | 3 | ||
 Spain | Albert Ramos | 43 | 4 | |
 Uzbekistan | Denis Istomin | 44 | 5 | |
| Robin Haase | 45 | 6 | ||
| Spain | Albert Montañés | 69 | 7 | |
 Italy | Flavio Cipolla | 70 | 8 |
The following players received wildcards into the main draw:
The following players received entry as a special exempt into the main draw:
The following players received entry from the qualifying draw:
| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Pakistan | Aisam-ul-Haq Qureshi | Jean-Julien Rojer | 50 | 1 | ||
| Eric Butorac | Bruno Soares | 55 | 2 | |||
 Australia | Paul Hanley | Marcelo Melo | 67 | 3 | ||
 Austria | Julian Knowle | David Marrero | 84 | 4 |
The following pairs received wildcards into the doubles main draw:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Italy | Roberta Vinci | 18 | 1 | |
 Russian Federation | Maria Kirilenko | 20 | 2 | |
| Spain | Anabel Medina Garrigues | 26 | 3 | |
 Czech Republic | Petra Cetkovská | 30 | 4 | |
 China | Zheng Jie | 32 | 5 | |
 Estonia | Kaia Kanepi | 33 | 6 | |
| Russian Federation | Nadia Petrova | 34 | 7 | |
| Polona Hercog | 36 | 9 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following player received entry as lucky loser:
Jarmila Gajdošová (left ankle injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
| Russian Federation | Russian Federation | |||||
| Sania Mirza | Anastasia Rodionova | 27 | 2 | |||
 Kazakhstan | Yaroslava Shvedova | Galina Voskoboeva | 35 | 3 | ||
| Australia | Jarmila Gajdošová | Andrea Hlaváčková | 43 | 4 |
The following pairs received wildcards into the doubles main draw:
The following pairs received entry as alternates:
Maria Kirilenko (right ankle injury) Jarmila Gajdošová (left ankle injury)See main article: 2012 Estoril Open – Men's singles.
Juan Martín del Potro defeated Richard Gasquet, 6–4, 6–2See main article: 2012 Estoril Open – Women's singles.
Kaia Kanepi defeated Carla Suárez Navarro, 3–6, 7–6(8–6), 6–4See main article: 2012 Estoril Open – Men's doubles.
Aisam-ul-Haq Qureshi / Jean-Julien Rojer defeated Julian Knowle / David Marrero, 7–5, 7–5See main article: 2012 Estoril Open – Women's doubles.
Zhang Shuai defeated Yaroslava Shvedova / Galina Voskoboeva, 4–6, 6–1, [11–9]
