The preliminary stages of the 2012 Copa Bridgestone Sudamericana de Clubes consisted of two stages:[1]
The draw was made in Luque on June 29, 2012.[3] Thirty-two teams (all from rest of South America) competed in the First Stage, where they were drawn into sixteen ties. The sixteen winners of the First Stage joined another fourteen teams (six from Argentina, eight from Brazil) to compete in the Second Stage, where they were drawn into fifteen ties.
Teams played in two-legged ties on a home-away basis. Each team earned 3 points for a win, 1 point for a draw, and 0 points for a loss. The following criteria were used for breaking ties on points:[4]
The fifteen winners of the Second Stage advanced to the round of 16 to join the defending champion Universidad de Chile.
Team 1 played the second leg at home.
|-!colspan=6|South Zone|-!colspan=6|North Zone|}
----Olimpia won on points 4–1.
----Tied on points 3–3, Nacional won on goal difference.
----Universidad Católica won on points 4–1.
----Tied on points 3–3, Guaraní won on away goals.
----Liverpool won in points 6–0.
----Aurora won in points 4–1.
----Cobreloa won on points 4–1.
----Cerro Porteño won on points 4–1.
----Millonarios won on points 4–1.
----Emelec won on points 4–1.
----Mineros won on points 6–0.
----Barcelona won on points 4–1.
----Deportes Tolima won on points 4–1.
----Deportivo Quito won on points 6–0.
----Envigado won on points 4–1.
----LDU Loja won on points 6–0.
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----Millonarios won on points 4–1.
----São Paulo won on points 6–0.
----Note: Second leg postponed from September 19 due to bad weather.[5]
Liverpool won on points 4–1.
----Tigre won on points 6–0.
----Cerro Porteño won on points 4–1.
----Tied on points 2–2, Atlético Goianiense won on penalties.
----Emelec won on points 4–1.
----Tied on points 3–3, Grêmio won on away goals.
----Barcelona won on points 4–1.
----Tied on points 3–3, Universidad Católica won on away goals.
----Colón won on points 6–0.
----Deportivo Quito won on points 6–0.
----Tied on points 2–2, Independiente won on away goals.
----Tied on points 3–3, LDU Loja won on away goals.
----Tied on points 3–3, Palmeiras won on away goals.