The 2012 Copa Bionaire is a professional tennis tournament played on Clay courts. It is the sixth edition of the tournament which was part of the 2012 ITF Women's Circuit. The event took place in Cali, Colombia between 6 and 12 February 2012. It offered the prize of US$ 100,000.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 New Zealand | Marina Erakovic | 56 | 1 | |
 Romania | Alexandra Dulgheru | 61 | 2 | |
 France | Mathilde Johansson | 73 | 3 | |
 Spain | Lourdes Domínguez Lino | 82 | 4 | |
 Austria | Patricia Mayr-Achleitner | 96 | 5 | |
 Czech Republic | Eva Birnerová | 102 | 6 | |
 Russian Federation | Alexandra Panova | 109 | 7 | |
| Romania | Alexandra Cadanțu | 112 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
The following players received entry by a lucky loser spot:
See main article: 2012 Copa Bionaire – Singles.
Alexandra Dulgheru def. 
Mandy Minella, 6 - 3, 1 - 6, 6 - 3
See main article: 2012 Copa Bionaire – Doubles.
Karin Knapp / Mandy Minella def. Alexandra Cadanțu / Raluca Olaru, 6–4, 6–3
