| Date: | 6–12 August |
| Edition: | 25th |
| Location: | Aptos, California, United States |
| Champs: |  Steve Johnson |
| Champd: | Rik de Voest /  John Peers |
The 2012 Comerica Bank Challenger was a professional tennis tournament played on hard courts. It was the 24th edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Aptos, California, United States between 6 and 12 August July 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Brian Baker | 62 | 1 | ||
 Russian Federation | Igor Andreev | 92 | 2 | |
| Rajeev Ram | 93 | 3 | ||
| Igor Sijsling | 102 | 4 | ||
| Tobias Kamke | 107 | 5 | ||
 France | Florent Serra | 132 | 6 | |
| Izak van der Merwe | 152 | 7 | ||
| Denis Kudla | 164 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2012 Comerica Bank Challenger – Singles.
Steve Johnson def. 
Robert Farah, 6–3, 6–3See main article: 2012 Comerica Bank Challenger – Doubles.
John Peers def. Chris Guccione / Frank Moser, 6–7(5–7), 6–1, [10–4]