See main article: 2012 Città di Como Challenger. Federico Delbonis and Renzo Olivo were the defending champions but Delbonis decided not to participate.
Olivo played alongside Dane Propoggia.
Philipp Marx and Florin Mergea won the title, defeating Colin Ebelthite and Jaroslav Pospíšil 6–4, 4–6, [10–4] in the final.