The 2012 Città di Caltanissetta was a professional tennis tournament played on clay courts. It was the 14th edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Caltanissetta, Italy between 4 and 10 June 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Colombia | Alejandro Falla | 52 | 1 | |
 Italy | Paolo Lorenzi | 86 | 2 | |
| Frederico Gil | 107 | 3 | ||
 Spain | Roberto Bautista Agut | 116 | 4 | |
| Antonio Veić | 119 | 5 | ||
 Brazil | Rogério Dutra da Silva | 121 | 6 | |
| Spain | Daniel Gimeno Traver | 125 | 7 | |
 Slovenia | Grega Žemlja | 129 | 8 |
The following players received wildcards into the singles main draw:
Marco Cecchinato Alejandro Falla Gianluca Naso Tommy RobredoThe following players received entry from the qualifying draw:
See main article: 2012 Città di Caltanissetta – Singles.
Tommy Robredo def. Gastão Elias, 6–3, 6–2See main article: 2012 Città di Caltanissetta – Doubles.
Daniel Gimeno Traver / Iván Navarro, 5–7, 7–6(7–5), [10–6]
