| Date: | 29 October – 4 November |
| Edition: | 4th |
| Surface: | Hard (indoor) |
| Location: | Charlottesville, United States |
| Champs: |  Denis Kudla |
| Champd: |  John Peers / John-Patrick Smith |
| Before Name: | Virginia National Bank Men's Pro Championship |
| After Name: | Charlottesville Men's Pro Challenger |
| Before Year: | 2011 |
| After Year: | 2013 |
The 2012 Charlottesville Men's Pro Challenger was a professional tennis tournament played on hard courts. It was the fourth edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Charlottesville, United States between October 29 and November 4, 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Jesse Levine | 69 | 1 | ||
 Russian Federation | Alex Bogomolov Jr. | 96 | 2 | |
| Michael Russell | 102 | 3 | ||
| Mischa Zverev | 140 | 4 | ||
| Ryan Sweeting | 146 | 5 | ||
| Bobby Reynolds | 152 | 6 | ||
| Tim Smyczek | 158 | 7 | ||
| Denis Kudla | 162 | 8 |
The following players received wildcards into the singles main draw:
Somdev Devvarman Alexander Domijan Austin Krajicek Michael McCluneThe following players received entry from the qualifying draw:
Taro Daniel Eric Quigley Mac StyslingerSee main article: 2012 Charlottesville Men's Pro Challenger – Singles.
Denis Kudla def. Alex Kuznetsov, 6–0, 6–3See main article: 2012 Charlottesville Men's Pro Challenger – Doubles.
John Peers / John-Patrick Smith def. Jarmere Jenkins / Jack Sock, 7–5, 6–1