The 2012 Challenger La Manche was a professional tennis tournament played on indoor hard courts. It was the 19th edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Cherbourg, France between February 27 and March 4, 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Édouard Roger-Vasselin | 95 | 1 | |
| Thomas Schoorel | 139 | 2 | ||
| France | Marc Gicquel | 142 | 3 | |
| France | Florent Serra | 143 | 4 | |
 Russian Federation | Alexander Kudryavtsev | 145 | 5 | |
| Igor Sijsling | 147 | 6 | ||
| France | Arnaud Clément | 155 | 7 | |
 Belgium | David Goffin | 164 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry as a special exempt into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2012 Challenger La Manche – Singles. Josselin Ouanna def. Maxime Teixeira, 6–3, 6–2
See main article: 2012 Challenger La Manche – Doubles. 
Laurynas Grigelis / 
Uladzimir Ignatik def. Dustin Brown / 
Jonathan Marray 4–6, 7–6(11–9), [10–0]
