The 2012 Campeonato Internacional de Tenis de Santos was a professional tennis tournament played on clay courts. It was the second edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Santos, Brazil between 16 and 22 April 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Brazil | João Souza | 99 | 1 | |
 Slovenia | Blaž Kavčič | 112 | 2 | |
| Paul Capdeville | 121 | 3 | ||
 Argentina | Diego Junqueira | 123 | 4 | |
| Brazil | Rogério Dutra da Silva | 129 | 5 | |
| Brazil | Ricardo Mello | 130 | 6 | |
| Brazil | Thiago Alves | 160 | 7 | |
| Argentina | Máximo González | 161 | 8 |
The following players received wildcards into the singles main draw:
Enrique Bogo Felipe Soares João Pedro Sorgi João SouzaThe following players received entry from the qualifying draw:
See main article: 2012 Campeonato Internacional de Tenis de Santos – Singles.
Ivo Minář def. Ricardo Hocevar, 4–6, 6–1, 6–4See main article: 2012 Campeonato Internacional de Tenis de Santos – Doubles.
Andrés Molteni / Marco Trungelliti def. Rogério Dutra da Silva / Júlio Silva, 6–4, 6–3