The 2012 Brussels Open was a women's tennis tournament played on outdoor clay courts. It was the 2nd edition of the Brussels Open, and was part of the Premier-level tournaments of the 2012 WTA Tour. The event took place at the Royal Primerose Tennis Club in Brussels, Belgium, from May 19 through May 26, 2012. Agnieszka Radwańska won the singles title.
See main article: 2012 Brussels Open – Singles. 
Agnieszka Radwańska defeated 
Simona Halep 7–5, 6–0
See main article: 2012 Brussels Open – Doubles. 
Bethanie Mattek-Sands / 
Sania Mirza defeated Alicja Rosolska / 
Zheng Jie 6–3, 6–2
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Poland | Agnieszka Radwańska | 3 | 1 | |
 France | Marion Bartoli | 7 | 2 | |
 Slovakia | Dominika Cibulková | 17 | 4 | |
 Italy | ||||
 Serbia | Jelena Janković | 20 | 6 | |
| China | Peng Shuai | 23 | 7 | |
 Estonia | Kaia Kanepi | 25 | 8 | |
 Russian Federation | Anastasia Pavlyuchenkova | 26 | 9 | |
| Russian Federation | Nadia Petrova | 30 | 10 |
The following players received wildcards into the main draw:
The following players received entry from the qualifying draw:
The following players received entry as lucky losers:
Bojana Jovanovski 
Lesia Tsurenko Sara Errani Daniela Hantuchová (foot stress fracture) Roberta Vinci (right wrist injury)| Country | Player | Country | Player | Rank1 | Seed | |
|---|---|---|---|---|---|---|
 Czech Republic | Květa Peschke | Katarina Srebotnik | 7 | 1 | ||
| Raquel Kops-Jones | Abigail Spears | 46 | 2 | |||
| Poland | Alicja Rosolska | Zheng Jie | 68 | 3 | ||
| United States | Bethanie Mattek-Sands | Sania Mirza | 71 | 4 |
The following pair received wildcard into the doubles main draw:
The following pair received entry as alternates:
Ksenia Pervak (knee injury)