See main article: 2012 BNP Paribas Open.
Roger Federer defeated John Isner in the final, 7–6(9–7), 6–3 to win the men's singles tennis title at the 2012 Indian Wells Masters. It was his record fourth Indian Wells title.
Novak Djokovic was the defending champion, but lost to Isner in the semifinals.
All seeds received a bye into the second round.