The 2012 BCR Open Romania Ladies was a professional tennis tournament played on outdoor clay courts. It was the 6th edition of the tournament and was part of the 2012 ITF Women's Circuit. It took place in Bucharest, Romania between 16 and 22 July 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 France | Alizé Cornet | 55 | 1 | |
| Romina Oprandi | 66 | 2 | ||
 Romania | Irina-Camelia Begu | 73 | 3 | |
| Romania | Alexandra Cadanțu | 85 | 4 | |
| France | Pauline Parmentier | 97 | 5 | |
 Spain | Laura Pous Tió | 102 | 6 | |
| France | Virginie Razzano | 104 | 7 | |
| Spain | Garbiñe Muguruza | 105 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Rocío de la Torre-Sánchez María-Teresa Torró-FlorSee main article: 2012 BCR Open Romania Ladies – Singles.
María-Teresa Torró-Flor def. Garbiñe Muguruza, 6–3, 4–6, 6–4See main article: 2012 BCR Open Romania Ladies – Doubles.
Irina-Camelia Begu / Alizé Cornet def. Elena Bogdan / Raluca Olaru, 6–2, 6–0