The 2012 Audi Melbourne Pro Tennis Classic was a professional tennis tournament played on clay courts. It was the seventh edition of the tournament which was part of the 2012 ITF Women's Circuit. It took place in Indian Harbour Beach, Florida, United States between 30 April and 6 May 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Irina Falconi | 104 | 1 | ||
 Australia | Olivia Rogowska | 121 | 2 | |
| Alison Riske | 128 | 3 | ||
 Italy | Camila Giorgi | 129 | 4 | |
| Michelle Larcher de Brito | 143 | 5 | ||
| Julia Cohen | 147 | 6 | ||
| Coco Vandeweghe | 163 | 1 | ||
| Madison Brengle | 183 | 2 |
The following players received wildcards into the singles main draw:
Jan Abaza Alexandra Kiick Maria Sanchez Chalena SchollThe following players received entry from the qualifying draw:
Krista Hardebeck Lena Litvak
Valeria Solovieva
Alyona SotnikovaThe following players received entry by a lucky loser spot:
The following players received entry by a Special Exempt:
See main article: 2012 Audi Melbourne Pro Tennis Classic – Singles.
Grace Min def. Maria Sanchez, 6–4, 7–6(7–4)See main article: 2012 Audi Melbourne Pro Tennis Classic – Doubles.
Maria Fernanda Alves / Jessica Moore def. 
Marie-Ève Pelletier / Alyona Sotnikova, 6–7(6–8), 6–3, [10–8]