| Date: | 10–16 September |
| Edition: | 25th |
| Surface: | Hard |
| Location: | Istanbul, Turkey |
| Champs: |  Dmitry Tursunov |
| Champd: |  Karol Beck /  Lukáš Dlouhý |
The 2012 American Express – TED Open was a professional tennis tournament played on hard courts. It was the 25th edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Istanbul, Turkey between 10 and 16 September 2012.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Tunisia | Malek Jaziri | 89 | 1 | |
| Rajeev Ram | 95 | 2 | ||
 Slovenia | Grega Žemlja | 99 | 3 | |
| Michael Russell | 107 | 4 | ||
| Matthias Bachinger | 115 | 5 | ||
| Russian Federation | Igor Kunitsyn | 126 | 6 | |
| Slovakia | Karol Beck | 143 | 7 | |
| Russian Federation | Dmitry Tursunov | 144 | 8 |
The following players received wildcards into the singles main draw:
Haluk Akkoyun Durukan Durmus Baris Erguden Efe YurtacanThe following players received entry from the qualifying draw:
See main article: 2012 American Express – TED Open – Singles.
Dmitry Tursunov def. 
Adrian Mannarino, 6–4, 7–6(7–5)See main article: 2012 American Express – TED Open – Doubles.
Karol Beck / Lukáš Dlouhý def. 
Adrián Menéndez / 
John Peers, 3–6, 6–2, [10–6]
