The women's 4 × 400 metres relay at the 2012 African Championships in Athletics was held at the Stade Charles de Gaulle on 1 July.[1]
| Gold | Endurance Abinuwa, Omolara Omotosho Margaret Etim, Bukola Abogunloko | |
| Silver | Goitseone Seleka, Lydia Mashila Oarabile Babolayi, Amantle Montsho | |
| Bronze | Mame Fatou Faye, Amy Mbacké Thiam Fatou Diabaye, Ndeye Fatou Soumah |
| Standing records prior to the 2012 African Championships in Athletics | |||||
|---|---|---|---|---|---|
| World record | Tatyana Ledovskaya, Olga Nazarova Mariya Pinigina, Olha Bryzhina | 3:15.17 | Seoul, South Korea | 1 October 1988 | |
| African record | Olabisi Afolabi, Fatima Yusuf Charity Opara, Falilat Ogunkoya | 3:21.04 | Atlanta, United States | 3 August 1996 | |
| Championship record | Shade Abugan, Margaret Etim Bukola Abogunloko, Muizat Ajoke Odumosu | 3:29.26 | Nairobi, Kenya | 1 August 2010 | |
| Broken records during the 2012 African Championships in Athletics | |||||
| Championship record | Endurance Abinuwa, Omolara Omotosho Margaret Etim, Bukola Abogunloko | 3:28.77 | Porto Novo, Benin | 1 July 2012 | |
| Rank | Lane | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|
| 8 | 3:28.77 | CR | ||||
| 6 | 3:31.27 | NR | ||||
| 7 | 3:31.64 | |||||
| 4 | 3:33.21 | |||||
| 3 | 3:33.24 | NR | ||||
| 1 | 3:35.06 | |||||
| 2 | Tigst Assefa, Wesene Belay, Mariet Mulugeta, Salam Abrhaley | 3:41.10 | ||||
| 5 | 3:41.46 |