The women's 4 x 100 metres relay at the 2012 African Championships in Athletics was held at the Stade Charles de Gaulle on 29 June.
| Gold | Christy Udoh, Gloria Asumnu Oludamola Osayomi, Lawretta Ozoh | |
| Silver | Rosina Amenebede, Flings Owusu-Agyapong Beatrice Gyaman, Janet Amponsah | |
| Bronze | Marie Josée Ta Lou, Amandine Allou Affoue Mireille Parfaite Gaha, Adeline Gouenon |
| Standing records prior to the 2012 African Championships in Athletics | |||||
|---|---|---|---|---|---|
| World record | Silke Gladisch, Sabine Rieger Ingrid Auerswald, Marlies Göhr | 41.37 | Canberra, Australia | 6 October 1985 | |
| African record | Beatrice Utondu, Faith Idehen Christy Opara-Thompson, Mary Onyali-Omagbemi | 42.39 | Barcelona, Spain | 7 August 1992 | |
| Championship record | Lawretta Ozoh, Agnes Osazuwa Oludamola Osayomi, Blessing Okagbare | 43.45 | Nairobi, Kenya | 30 July 2010 | |
| Broken records during the 2012 African Championships in Athletics | |||||
| Championship record | Christy Udoh, Gloria Asumnu Oludamola Osayomi, Lawretta Ozoh | 43.21 | Porto Novo, Benin | 29 June 2012 | |
| Rank | Lane | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|
| 7 | 43.21 | CR | ||||
| 5 | 44.35 | |||||
| 8 | 45.29 | |||||
| 6 | 45.56 | |||||
| 2 | 47.28 | |||||
| 5 | 48.67 | |||||
| 3 |