The men's 4 x 100 metres relay at the 2012 African Championships in Athletics was held at the Stade Charles de Gaulle on 28 and 29 June.
| Gold | Hannes Dreyer, Simon Magakwe Roscoe Engel, Thuso Mpuang | |
| Silver | Peter Emelieze, Obinna Metu Adetoyi Durotoye, Ogho-Oghene Egwero | |
| Bronze | Emmanuel Kubi, Tim Abeyie Ashhad Agyapong, Allah Laryea-Akrong |
| Standing records prior to the 2012 African Championships in Athletics | |||||
|---|---|---|---|---|---|
| World record | Nesta Carter, Michael Frater Yohan Blake, Usain Bolt | 37.04 | Daegu, South Korea | 4 September 2011 | |
| African record | Osmond Ezinwa, Olapade Adeniken Francis Obikwelu, Davidson Ezinwa | 37.94 | Athens, Greece | 9 August 1997 | |
| Championship record | Hannes Dreyer, Corne Du Plessis Sergio Mullins, Thuso Mpuang | 38.75 | Addis Ababa, Ethiopia | 2 May 2008 | |
| Date | Time | Round | |
|---|---|---|---|
| 28 June 2012 | 17:35 | Round 1 | |
| 29 June 2012 | 17:50 | Final |
First 3 in each heat (Q) and 2 best performers (q) advance to the Final.
| Rank | Heat | Lane | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|---|
| 1 | 1 | 6 | 39.38 | Q | |||
| 2 | 1 | 5 | 39.47 | Q | |||
| 3 | 1 | 7 | 39.48 | Q | |||
| 4 | 2 | 3 | 40.19 | Q | |||
| 5 | 1 | 4 | 40.24 | q | |||
| 6 | 2 | 4 | 40.27 | Q | |||
| 7 | 1 | 3 | 40.42 | q, NR | |||
| 8 | 2 | 5 | 40.51 | Q | |||
| 9 | 2 | 7 | 41.33 | ||||
| 10 | 2 | 6 | 41.44 | ||||
| 1 | 2 | ||||||
| 1 | 8 | ||||||
| 2 | 2 |
| Rank | Lane | Nation | Athletes | Time | Notes | |
|---|---|---|---|---|---|---|
| 4 | 39.26 | |||||
| 8 | 39.34 | |||||
| 6 | 39.40 | |||||
| 3 | 40.10 | |||||
| 2 | 40.16 | |||||
| 7 | 40.42 | |||||
| 5 | Josias Mevognon, Inoussa Kassim, Wilcox Ernest Bamd Makou, Fiacre Brisso Bahorou | 40.86 | ||||
| 1 |