The 2012 Aberto de São Paulo was a professional tennis tournament played on hard courts. It was the twelfth edition of the tournament which is part of the 2012 ATP Challenger Tour. It took place in São Paulo, Brazil between 2 and 8 January 2011.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Argentina | Horacio Zeballos | 109 | 1 | |
 Brazil | Rogério Dutra da Silva | 124 | 2 | |
| Brazil | Júlio Silva | 153 | 3 | |
| Argentina | Federico Delbonis | 166 | 4 | |
| Gastão Elias | 172 | 5 | ||
| Brazil | Caio Zampieri | 253 | 6 | |
 Colombia | Eduardo Struvay | 254 | 7 | |
| Argentina | Juan Pablo Brzezicki | 262 | 8 |
The following players received wildcards into the singles main draw:
Henrique Cunha Daniel Dutra da Silva Leonardo Kirche Thiago MonteiroThe following players received entry from the qualifying draw:
Augusto Laranja Jose Pereira Bruno Sant'anna Maximiliano EstévezSee main article: 2012 Aberto de São Paulo – Singles. Thiago Alves def. Gastão Elias, 7–6(7–5), 7–6(7–1)[1]
See main article: 2012 Aberto de São Paulo – Doubles. Fernando Romboli / Júlio Silva def. 
Jozef Kovalík / José Pereira, 7–5, 6–2