The 2012 AON Open Challenger was a professional tennis tournament played on clay courts. It was the ninth edition of the tournament which was part of the 2012 ATP Challenger Tour. It took place in Genoa, Italy between 3 and 9 September 2012.
| Country | Player | Rank1 | Seed |
|---|---|---|---|
 Italy | Andreas Seppi | 27 | 1 |
| Italy | Fabio Fognini | 59 | 2 |
| Italy | Paolo Lorenzi | 69 | 3 |
| Italy | Filippo Volandri | 72 | 4 |
| Italy | Simone Bolelli | 84 | 5 |
 Czech Republic | Lukáš Rosol | 91 | 6 |
 Spain | Albert Montañés | 111 | 7 |
| Frederico Gil | 113 | 8 | |
| Dustin Brown | 142 | ||
| Italy | Alessandro Giannessi | 162--> |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: 2012 AON Open Challenger – Singles.
Albert Montañés def. Tommy Robredo, 6–4, 6–1See main article: 2012 AON Open Challenger – Doubles.
Philipp Oswald, 6–3, 6–1