| Club: | Sampdoria |
| Season: | 2012–13 |
| Stadium: | Stadio Luigi Ferraris |
| League: | Serie A |
| League Result: | 14th |
| Cup1: | Coppa Italia |
| Cup1 Result: | First round |
| League Topscorer: | Mauro Icardi (10) |
| Season Topscorer: | Mauro Icardi (10) |
| Prevseason: | 2011–12 |
| Nextseason: | 2013–14 |
The 2012–13 season was Sampdoria's 66th in existence. Sampdoria finished the 2011–12 season in sixth place in Serie B and were promoted to Serie A through the play-offs.
|-! colspan="10" style="background:#dcdcdc; text-align:center"| Goalkeepers|-! colspan="10" style="background:#dcdcdc; text-align:center"| Defenders|-! colspan="10" style="background:#dcdcdc; text-align:center"| Midfielders|-! colspan="10" style="background:#dcdcdc; text-align:center"| Forwards|-! colspan="10" style="background:#dcdcdc; text-align:center"| Players transferred out during the season
This includes all competitive matches. The list is sorted by shirt number when total goals are equal.
| width=15 | width=15 | width=15 | width=15 | width=150 | Name | width=80 | Serie A | width=80 | Coppa Italia | width=80 | Total | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 98 | FW |  | Mauro Icardi | 10 | 0 | 10 | ||||||||
| 2 | 23 | FW |  | Éder | 7 | 0 | 7 | ||||||||
| 3 | 10 | FW | | Maxi López | 4 | 1 | 5 | ||||||||
| 4 | 6 | MF |  | Enzo Maresca | 3 | 0 | 3 | ||||||||
| = | 11 | MF | | Gianni Munari | 3 | 0 | 3 | ||||||||
| = | 16 | MF | | Andrea Poli | 3 | 0 | 3 | ||||||||
| 7 | Own goals | 2 | 0 | 2 | |||||||||||
| = | 2 | MF | Marcelo Estigarribia | 2 | 0 | 2 | |||||||||
| = | 12 | FW | | Gianluca Sansone | 2 | 0 | 2 | ||||||||
| = | 19 | DF | | Lorenzo De Silvestri | 2 | 0 | 2 | ||||||||
| 11 | 3 | DF | | Andrea Costa | 1 | 0 | 1 | ||||||||
| = | 9 | FW | | Nicola Pozzi | 1 | 0 | 1 | ||||||||
| = | 14 | MF |  | Pedro Obiang | 1 | 0 | 1 | ||||||||
| = | 25 | MF |  | Nenad Krstičić | 1 | 0 | 1 | ||||||||
| = | 28 | DF | | Daniele Gastaldello | 1 | 0 | 1Sources |