| Score: | 6–3, 6–2 |
| Draw: | 48 (5) |
| Seeds: | 16 |
See main article: 2011 Wimbledon Championships. Leander Paes and Cara Black were the defending champions but lost in the quarterfinals to Daniel Nestor and Chan Yung-jan.
Jürgen Melzer and Iveta Benešová defeated Mahesh Bhupathi and Elena Vesnina in the final, 6–3, 6–2 to win the mixed doubles tennis title at the 2011 Wimbledon Championships.[1]
All seeds received a bye into the second round.
See also: 1 and 1. 
Bob Bryan / Liezel Huber (quarterfinals, withdrew)
See also: 2 and 4. 
Max Mirnyi / 
Yaroslava Shvedova (second round)
See also: 3 and 2. 
Nenad Zimonjić / Katarina Srebotnik (third round, withdrew)
See also: 4 and 3. 
Mahesh Bhupathi / 
Elena Vesnina (final)
See also: 5 and 3. 
Aisam-ul-Haq Qureshi / 
Květa Peschke (second round)
See also: 6 and 4. Rohan Bopanna / Sania Mirza (quarterfinals)
See also: 7 and 1. Philipp Petzschner / Barbora Záhlavová-Strýcová (second round)
See also: 8 and 2. 
Daniel Nestor / Chan Yung-jan (semifinals)
See also: 9 and 1. 
Jürgen Melzer / Iveta Benešová (champions)
See also: 10 and 3. 
Dick Norman / Lisa Raymond (second round)
See also: 11 and 2. Mark Knowles / Nadia Petrova (third round)
See also: 12. 
Daniele Bracciali / Flavia Pennetta (withdrew)
See also: 13 and 3. František Čermák / Lucie Hradecká (second round)
See also: 14 and 2. Leander Paes / Cara Black (quarterfinals)
See also: 15 and 4. 
Andy Ram / Meghann Shaughnessy (third round)
See also: 16 and 1. 
David Marrero / Andrea Hlaváčková (second round)