See main article: 2011 Sony Ericsson Open.
Victoria Azarenka defeated Maria Sharapova in the final, 6–1, 6–4 to win the women's singles tennis title at the 2011 Miami Open. It was her second Miami Open title.
Kim Clijsters was the defending champion, but lost to Victoria Azarenka in the quarterfinals in a rematch of the previous year's fourth-round match.
All seeds received a bye into the second round.
See main article: 2011 Sony Ericsson Open – Women's singles qualifying.