The 2011 Santos Brasil Tennis Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which was part of the 2011 ATP Challenger Tour. It took place in Santos, Brazil between 18 and 24 April 2011.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Brazil | Ricardo Mello | 89 | 1 | |
| Brazil | Marcos Daniel | 105 | 2 | |
 France | Éric Prodon | 125 | 3 | |
 Japan | Tatsuma Ito | 135 | 4 | |
 Argentina | Diego Junqueira | 142 | 5 | |
| Argentina | Leonardo Mayer | 161 | 6 | |
| Brazil | João Souza | 174 | 7 | |
| Argentina | Juan Pablo Brzezicki | 176 | 8 |
The following players received wildcards into the singles main draw:
Daniel Bustamante Daniel Dutra da Silva
Christian Lindell José PereiraThe following players received entry into the singles main draw as a special exemption:
The following players received entry from the qualifying draw:
See main article: 2011 Santos Brasil Tennis Open – Singles. João Souza def. Diego Junqueira, 6–4, 6–2
See main article: 2011 Santos Brasil Tennis Open – Doubles. Franco Ferreiro / André Sá def. 
Gerald Melzer / José Pereira, 6–3, 6–3
