The 2011 Samarkand Challenger was a professional tennis tournament played on clay courts. It was the 15th edition of the tournament which was part of the 2011 ATP Challenger Tour. It took place in Samarkand, Uzbekistan between 8 and 14 August 2011.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Uzbekistan | Denis Istomin | 81 | 1 | |
 Russian Federation | 149 | 2 | ||
| Igor Sijsling | 178 | 3 | ||
 Romania | Victor Crivoi | 182 | 4 | |
 Slovakia | Andrej Martin | 193 | 5 | |
 Tunisia | Malek Jaziri | 230 | 6 | |
 France | Jonathan Dasnières de Veigy | 244 | 7 | |
| Slovakia | Ivo Klec | 246 | 8 |
The following players received wildcards into the singles main draw:
Murad Inoyatov Denis Istomin Nigmat ShofayzievThe following players received entry from the qualifying draw:
Sarvar Ikramov Temur Ismailov Alexander Kudryavtsev
Divij SharanThe following players received entry from the qualifying draw as a lucky loser:
Jakhongir Jalalov Vaja UzakovSee main article: 2011 Samarkand Challenger – Singles. Denis Istomin def. Malek Jaziri, 7–6(7–2), ret.
See main article: 2011 Samarkand Challenger – Doubles. Michail Elgin / Alexander Kudryavtsev def. 
Radu Albot / Andrey Kuznetsov, 7–6(7–4), 2–6, [10–7]