The 2011 São Léo Open was a professional tennis tournament played on clay courts. It was the first edition of the tournament which is part of the 2011 ATP Challenger Tour. It took place in São Leopoldo, Brazil between 31 October and 6 November 2011.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Rui Machado | 80 | 1 | ||
 Argentina | Diego Junqueira | 91 | 2 | |
| Frederico Gil | 96 | 3 | ||
| Argentina | Leonardo Mayer | 99 | 4 | |
 Brazil | Ricardo Mello | 109 | 5 | |
 Spain | Rubén Ramírez Hidalgo | 130 | 6 | |
| Argentina | Máximo González | 131 | 7 | |
| Wayne Odesnik | 136 | 8 |
The following players received wildcards into the singles main draw:
Guilherme Clézar Franco Ferreiro André Ghem Bruno Sant'annaThe following players received entry as a special exempt into the singles main draw:
The following players received entry as an alternate into the singles main draw:
The following players received entry from the qualifying draw:
Marcelo Demoliner Pablo Galdón André Miele Marco TrungellitiSee main article: 2011 São Léo Open – Singles. Leonardo Mayer def. 
Nikola Ćirić, 7–5, 7–6(7–1)
See main article: 2011 São Léo Open – Doubles. Franco Ferreiro / Rubén Ramírez Hidalgo def. Gastão Elias / Frederico Gil, 6–7(4–7), 6–3, [11–9]