The 2011 Lexus of Las Vegas Open was a professional tennis tournament played on hard courts. It was the third edition of the tournament which was part of the 2011 ITF Women's Circuit. It took place in Las Vegas, United States between 26 September and 2 October 2011.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 Georgia | Anna Tatishvili | 85 | 1 | |
| Mirjana Lučić | 96 | 2 | ||
| Varvara Lepchenko | 101 | 3 | ||
 Romania | Edina Gallovits-Hall | 107 | 4 | |
| Melanie Oudin | 113 | 5 | ||
| Alison Riske | 117 | 6 | ||
| Jamie Hampton | 129 | 7 | ||
 Italy | Romina Oprandi | 131 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
Vasilisa Bardina
Gabriela Dabrowski
Duan Yingying
Krista HardebeckSee main article: 2011 Lexus of Las Vegas Open – Singles. Romina Oprandi def. Alexa Glatch, 6 - 7(2 - 7), 6 - 3, 7 - 6(7 - 4)
See main article: 2011 Lexus of Las Vegas Open – Doubles. Alexa Glatch / Mashona Washington def. Varvara Lepchenko / Melanie Oudin, 6 - 4, 6 - 2