See main article: 2011 Internazionali Femminili di Palermo. Kaia Kanepi was the defending champion, but decided not to participate.
5th seed Anabel Medina Garrigues defeated 7th seed Polona Hercog in the final, 6–3, 6–2.[1]
See main article: 2011 Internazionali Femminili di Palermo – Singles qualifying.