The 2011 Fifth Third Bank Tennis Championships was a professional tennis tournament played on hard courts. It was the 17th edition of the tournament which was part of the 2011 ATP Challenger Tour and the 12th edition for the 2011 ITF Women's Circuit. It took place in Lexington, Kentucky, United States between 18 and 24 July 2011.
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
 United Kingdom | James Ward | 202 | 1 | |
| Wayne Odesnik | 218 | 2 | ||
 Australia | Chris Guccione | 221 | 3 | |
| Fritz Wolmarans | 222 | 4 | ||
| Australia | Carsten Ball | 230 | 5 | |
| Michael Yani | 234 | 6 | ||
 Serbia | Ilija Bozoljac | 239 | 7 | |
 Bosnia and Herzegovina | Amer Delić | 246 | 8 |
The following players received wildcards into the singles main draw:
Alexis Musialek
Eric Quigley Jack Sock Rhyne WilliamsThe following players received entry from the qualifying draw:
The following players received entry as a lucky loser into the singles main draw:
| Country | Player | Rank1 | Seed | |
|---|---|---|---|---|
| Melanie Oudin | 100 | 1 | ||
| Alison Riske | 117 | 2 | ||
| Sloane Stephens | 131 | 3 | ||
 Ukraine | Tetiana Luzhanska | 157 | 4 | |
| Julia Cohen | 165 | 5 | ||
 Hungary | Melinda Czink | 167 | 6 | |
 Canada | Heidi El Tabakh | 185 | 7 | |
 Hong Kong | Zhang Ling | 194 | 8 |
The following players received wildcards into the singles main draw:
The following players received entry from the qualifying draw:
See main article: article and 2011 Fifth Third Bank Tennis Championships – Men's singles. Wayne Odesnik def. James Ward, 7–5, 6–4
See main article: article and 2011 Fifth Third Bank Tennis Championships – Women's singles. Chichi Scholl def. Amanda Fink, 6–1, 6–1
See main article: article and 2011 Fifth Third Bank Tennis Championships – Men's doubles. Jordan Kerr / David Martin def. James Ward / Michael Yani, 6–3, 6–4
See main article: article and 2011 Fifth Third Bank Tennis Championships – Women's doubles. 
Tamaryn Hendler / Chichi Scholl def. Lindsay Lee-Waters / Megan Moulton-Levy, 7–6(11–9), 3–6, [10–7]